The role of ARF and Rab GTPases in membrane transport.
نویسندگان
چکیده
Two key events of intracellular transport and membrane trafficking in eukaryotic cells, the formation of transport vesicles and their specific delivery to target membranes, are controlled by small GTPases of the ADP-ribosylation factor (ARF) and Rab families, respectively. The past 18 months have seen the identification of proteins that regulate ARF and Rab GDP/GTP cycle, as well as the characterization of their effectors, shedding light on the molecular mechanisms of ARF and Rab function.
منابع مشابه
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Figure 1: (Top) Ribbon representation of the Rab6GCC185 complex. Switch I (yellow) and II (orange) regions in Rab6 (blue) bind the GCC185 Rab binding domain (green). Rab6-bound GTP (stick model) and magnesium (sphere) are shown. (Bottom) View of the Rab6-GCC185 binding interface. Residues in GCC185 that are critical for Rab6 interaction and Golgi localization are labeled. An anomalous differenc...
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عنوان ژورنال:
- Current opinion in cell biology
دوره 11 4 شماره
صفحات -
تاریخ انتشار 1999